6-Ethoxypyridin-3-amine → (6-Ethoxy-pyridin-3-yl)-isopropyl-amine

HRID 900122ノート

反応式

HRID 900122 の反応式
Cl[C:2]1[N:7]=[CH:6][C:5]([NH:8][CH:9]([CH3:11])[CH3:10])=[CH:4][CH:3]=1.[CH2:12]([O:14]C1N=CC(N)=CC=1)[CH3:13]>CC(C)=O>[CH2:12]([O:14][C:2]1[N:7]=[CH:6][C:5]([NH:8][CH:9]([CH3:11])[CH3:10])=[CH:4][CH:3]=1)[CH3:13]

参加物

4

反応物 2

HCID 30403016-Ethoxypyridin-3-amineHCID 589579206-chloro-N-(propan-2-yl)pyridin-3-amine

生成物 1

HCID 58957938(6-Ethoxy-pyridin-3-yl)-isopropyl-amine

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Following the procedure described for Preparation 2(A), 6-ethoxy-pyridin-3-ylamine (10 g, 72.4 mmol) was reacted with acetone (4.8 mL) to provide 11.18 g of (6-ethoxy-pyridin-3-yl)-isopropyl-amine. 1H NMR (CD3OD) δ 7.48 (d, 1H), 7.11 (dd, 1H), 6.61 (d, 1H), 4.14 (q, 2H), 3.48 (m, 1H), 1.32 (t, 3H), 1.14 (d, 6H); MS 181.3 (M+1).

出典と根拠

ORDレコード
ord-962deba8319d4c39a96ddbc4e6364ddd
出典データセット
uspto-grants-2008_04
特許番号
US07358242B2

反応ノート

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