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llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0

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反応

Trichloroacetyl chloride → 1-(3-Methoxy-benzyl)-1H-imidazole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide

HRID 900252

印刷プレビュー

反応式

HRID 900252 の反応式

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:12]=[CH:13][CH:14]=1)[CH2:6][N:7]1[CH:11]=[CH:10][N:9]=[CH:8]1.CCN(CC)CC.ClC(Cl)(Cl)[C:24](Cl)=[O:25].[CH:29]([N:32]1[CH2:37][CH2:36][CH:35]([NH2:38])[CH2:34][CH2:33]1)([CH3:31])[CH3:30]>C(Cl)Cl>[CH:29]([N:32]1[CH2:37][CH2:36][CH:35]([NH:38][C:24]([C:8]2[N:7]([CH2:6][C:5]3[CH:12]=[CH:13][CH:14]=[C:3]([O:2][CH3:1])[CH:4]=3)[CH:11]=[CH:10][N:9]=2)=[O:25])[CH2:34][CH2:33]1)([CH3:31])[CH3:30]

参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 6420Trichloroacetyl chloride

HCID 8471Triethylamine2 回

HCID 31633331-(Propan-2-yl)piperidin-4-amine

HCID 122293911-(3-methoxy-benzyl)-1H-imidazole

生成物 1

HCID 104059941-(3-Methoxy-benzyl)-1H-imidazole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide

試薬・触媒・溶媒 1

HCID 6344

Dichloromethane

溶媒

実験手順

To a solution of 1-(3-methoxy-benzyl)-1H-imidazole (100 mg) and NEt3 (147 μL) in DCM (5 mL) was added trichloroacetyl chloride (106 μL) dropwise. The mixture was stirred for 2 h at RT. More NEt3 (147 μL) and 1-isopropyl-piperidin-4-ylamine (76 mg) were added and stirring was continued for 1 h at RT. The mixture was quenched by the addition of MeOH, concentrated and the residue was purified by preparative HPLC. The fractions containing the product were evaporated to provide 30 mg of the title compound as its trifluoroacetate salt. MS (ESI+): m/e=357.

後処理

stirringstirring
waitwas continued for 1 h at RT
customThe mixture was quenched by the addition of MeOH
concentrationconcentrated
customthe residue was purified by preparative HPLC
additionThe fractions containing the product
customwere evaporated

出典と根拠

ORDレコード: ord-2176587afdc241b88c9ae1bfea7a4413
出典データセット: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07358268B2

反応ノート

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