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Hydrochloric Acid → n-[(5-Chloro(2-thienyl))sulfonyl](4-nitrophenyl)carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-Nitrobenzoyl chloride | HCID 8502 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 5-Chlorothiophene-2-Sulfonamide | HCID 1241301 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | n-[(5-Chloro(2-thienyl))sulfonyl](4-nitrophenyl)carboxamide | HCID 22064472 | 81% |
反応手順
A 85 mg portion (0.43 mmol) of 5-chlorothiophenesulfonamide dissolved in 2 mL of acetone was treated with 110 μL of 4N NaOH (0.43 mmol) followed by addition of 80 mg (0.43 mmol) of 4-nitrobenzoyl chloride. After stirring for 12 h, the solution was acidfied 1N HCl and the precipitate was collected by filtration and dried. Recrystallization from EtOAc/hexane afforded 120 mg (81%) of the titled compound. ES-MS (M+H)+=347 (Cl).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07358257B2 |
| 出典データセット | uspto-grants-2008_04 |
| ORD ID | ord-addee6c8b3454f4faf5a4a4485967fa5 |
| 出典メモ | uspto-grants-2008_04 |