化工社化工社 化学情報印刷レポート · 研究参考用
1,8-Diazabicyclo(5.4.0)undec-7-ene → (Tert-butoxy)-n-[4-(2,4-dioxo(1,3-dihydroquinazolin-3-yl))phenyl]carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Methyl 2-isocyanatobenzoate | HCID 519494 | — |
| 反応物 | tert-Butyl (4-aminophenyl)carbamate | HCID 688611 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (Tert-butoxy)-n-[4-(2,4-dioxo(1,3-dihydroquinazolin-3-yl))phenyl]carboxamide | HCID 91580089 | 85% |
反応手順
To a solution of methyl 2-isocyanatobenzoate (0.97 g, 5.5 mmol) and Boc 1,4-phenylenediamine (1.04 g, 5 mmol) in THF (15 mL) was added DIEA (0.87 mL, 5 mmol) and DBU (0.75 mL, 5 mmol). The reaction mixture stirred at room temp for 5 hr. the off-white solid filtered and washed with ethyl ether to give desired compound (1.49 g, 85%). ES-MS (M+Na)+=376.1, (M-tBu+H)+=298.0.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07358257B2 |
| 出典データセット | uspto-grants-2008_04 |
| ORD ID | ord-6334983465274893a2fac15960b759ee |
| 出典メモ | uspto-grants-2008_04 |