関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | N-Fluorobenzenesulfonimide | HCID 588007 | — |
| 反応物 | 5-Chlorothiophene-2-sulfonic acid tert-butylamide | HCID 10106323 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | (Tert-butyl)[(5-chloro-3-fluoro(2-thienyl))sulfonyl]amine | HCID 22064462 | 108.2% |
反応手順
A THF solution (1.5 mL) of 128 mg (0.50 mmol) of (tert-butyl)[(5-chloro(2-thienyl))sulfonyl]amine was cooled to −78° C. and treated with 954 μL (1.5 mmol) of a 1.6 M solution of butyl lithium in hexane. After 1 h, 159 mg (0.5 mmol) of bis(phenylsulfonyl)fluoroamine was added and the solution was allowed to warm to 23° C. The reaction was quenched with 1 mL of sat. NH4Cl, extracted 3 times with diethyl ether, dried (MgSO4), concentrated in vacuo to afford a quantitative yield (147 mg) of the desire product. 19F-NMR (CDCl3) δ (ppm): −113.4.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07358257B2 |
|---|
| 出典データセット | uspto-grants-2008_04 |
|---|
| ORD ID | ord-b9726075593e46f5a80025deb39017e5 |
|---|
| 出典メモ | uspto-grants-2008_04 |
|---|
