3-Amino-5-(4-fluorophenyl)thiophene-2-carboxamide → 3-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-2-thiophenecarboxamide
反応式
[N-:1]=[C:2]=[O:3].[Na+].[NH2:5][C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[S:8][C:7]=1[C:18]([NH2:20])=[O:19]>C(O)(=O)C.O>[NH2:1][C:2]([NH:5][C:6]1[CH:10]=[C:9]([C:11]2[CH:12]=[CH:13][C:14]([F:17])=[CH:15][CH:16]=2)[S:8][C:7]=1[C:18]([NH2:20])=[O:19])=[O:3]参加物
5
実験手順
Sodium isocyanate (1.08 g) was added portionwise to a stirred suspension of 3-amino-5-(4-fluorophenyl)-2-thiophenecarboxamide (3.2 g) in acetic acid (150 mL) and water (90 mL). After 20 h, the solid was filtered off and washed with water, methanol and ether. Recrystallisation from methanol/dimethylsulphoxide gave the title urea (0.5 g) as a 1:1 dimethylsulphoxide solvate.
後処理
- filtrationthe solid was filtered off
- washwashed with water, methanol and ether
- customRecrystallisation from methanol/dimethylsulphoxide
出典と根拠
- ORDレコード
- ord-980b78b90efd4c4692f839fc19df05d9
- 出典データセット
- uspto-grants-2008_04
- 特許番号
- US07358376B2
反応ノート
読み込み中…