1-Butanaminium, N,N,N-tributyl-, fluoride, hydrate → HCID 9833987、化合物

HRID 900499ノート

反応式

HRID 900499 の反応式
[OH2:1].[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[Si]([CH2:27][CH2:28][C@H:29]([OH:35])[C:30]([CH3:34])([CH3:33])[C:31]#[N:32])(C(C)(C)C)(C)C>>[OH:1][CH2:27][CH2:28][C@H:29]([OH:35])[C:30]([CH3:34])([CH3:33])[C:31]#[N:32]

参加物

3

反応物 2

HCID 162116731-Butanaminium, N,N,N-tributyl-, fluoride, hydrateHCID 235679315-tert-butyldimethylsilyl-2,2-dimethyl-3(S)hydroxy-pentane-nitrile2 回

生成物 1

HCID 9833987HCID 9833987、化合物

実験手順

12.18 g (46.61 mmol) of tetrabutylammonium fluoride hydrate is added to a solution that consists of 3 g (11.65 mmol) of 5-tert-butyldimethylsilyl-2,2-dimethyl-3(S)hydroxy-pentane-nitrile of the title compound of Example 8b, dissolved in 40 ml of tetrahydrofaran, and it is stirred for 16 hours at room temperature. Then, it is evaporated to the dry state in a vacuum. The residue is purified by RP-18 chromatography (mobile solvent: acetonitrile/water gradient).

後処理

  1. dissolutiondissolved in 40 ml of tetrahydrofaran, and it
  2. customThen, it is evaporated to the dry state in a vacuum
  3. customThe residue is purified by RP-18 chromatography (mobile solvent: acetonitrile/water gradient)

出典と根拠

ORDレコード
ord-96c160347ea340c3b0be0989136b2815
出典データセット
uspto-grants-2008_04
特許番号
US07358382B2

反応ノート

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