Sodium Bicarbonate → 2-Amino-4-methyl-thiazole-5-sulfonic acid (2-dimethylamino-ethyl)-amide
反応式
[CH3:1][N:2]([CH3:19])[CH2:3][CH2:4][NH:5][S:6]([C:9]1[S:13][C:12]([NH:14]C(=O)C)=[N:11][C:10]=1[CH3:18])(=[O:8])=[O:7].C([O-])(O)=O.[Na+]>Cl>[CH3:1][N:2]([CH3:19])[CH2:3][CH2:4][NH:5][S:6]([C:9]1[S:13][C:12]([NH2:14])=[N:11][C:10]=1[CH3:18])(=[O:8])=[O:7]参加物
4
反応条件
- 温度
- 80 °C
実験手順
A stirred suspension of 2-acetamido-4-methyl-thiazole-5-sulfonic acid (2-dimethylamino-ethyl)-amide (1.0 g, 3.26 mmol) in 6N hydrochloric acid (13 ml) was heated for 2 h at 80° C., and 2N NaHCO3 solution (100 ml) was added. The mixture was extracted with ethyl acetate (3×50 ml), the combined organic layers washed with brine (50 ml) and dried (MgSO4). The crude product was further purified by crystallization (ethyl aceate) to yield the title compound (0.68 g, 79%) as a white solid. MS (ISP) 262.9 [(M−H)−]; mp 153° C.