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[2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acid → 4-chloro-N-{4-[2-(4-dimethylcarbamoylmethyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | [2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acid | HCID 677042 | — |
| 反応物 | N,N-dimethyl-2-(piperazin-1-yl)acetamide | HCID 2758642 | — |
| 生成物 | 4-chloro-N-{4-[2-(4-dimethylcarbamoylmethyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzamide | HCID 59698886 | — |
反応手順
In analogy to example 1.3, [2-(4-chloro-benzoylamino)-thiazol-4-yl]-acetic acid (example 1.2) was coupled with piperazino-acetic acid N,N-dimethylamide to give 4-chloro-N-{4-[2-(4-dimethylcarbamoylmethyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzamide, using general procedure A. Amorphous white solid. MS 450.0 ([M+H]+)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07361672B2 |
| 出典データセット | uspto-grants-2008_04 |
| ORD ID | ord-c85db3b31e494a0194d2e7e138c39184 |
| 出典メモ | uspto-grants-2008_04 |