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Ethyl 5-hydroxy-1H-indole-2-carboxylate → 5-[2-(1-Methyl-pyrrolidin-2-yl)-ethoxy]-1H-indole-2-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 5-hydroxy-1H-indole-2-carboxylate | HCID 90677 | — |
| 反応物 | 1-Methyl-2-pyrrolidineethanol | HCID 93363 | — |
| 反応物 | 5-[2-(1-methyl-pyrrolidin-2-yl)-ethoxy]-1H-indole-2-carboxylic acid ethyl ester | HCID 69283274 | — |
| 生成物 | 5-[2-(1-Methyl-pyrrolidin-2-yl)-ethoxy]-1H-indole-2-carboxylic acid | HCID 59699458 | — |
反応手順
According to the procedure described for the synthesis of Example 5/step 1 5-[2-(1-methyl-pyrrolidin-2-yl)-ethoxy]-1H-indole-2-carboxylic acid ethyl ester was synthesized from 5-hydroxy-1H-indole-2-carboxylic acid ethyl ester (commercially available) and 2-(1-methyl-pyrrolidin-2-yl)-ethanol (commercially available). The title compound was yielded in 38% as light brown foam. MS (m/e): 317.1 (MH+, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07361682B2 |
| 出典データセット | uspto-grants-2008_04 |
| ORD ID | ord-d2a1405bff534b2d9435c2d5b0cbac55 |
| 出典メモ | uspto-grants-2008_04 |