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N-[(Phenylmethoxy)carbonyl]-L-isoleucine → 2-(2-Methoxyphenyl)-8-(1-methylethyl)-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-[(Phenylmethoxy)carbonyl]-L-isoleucine | HCID 2724772 | — |
| 反応物 | 8-Butyl-7-(3-(imidazol-5-yl)-1-oxopropyl)-2-(2-methoxyphenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine | HCID 22928232 | — |
| 生成物 | 2-(2-Methoxyphenyl)-8-(1-methylethyl)-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrazine | HCID 22016811 | — |
反応手順
through 5.g. were carried out in a manner analogous to Steps 1.c. through 1.f of example 1, starting with Cbz-(L)-Ile-OH in place of Cbz-(L)-Nle-OH, and yielding 2-(2-methoxyphenyl)-8-(1-methylethyl)-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrazine (compound vii, where R3 is isobutyl, R4 is 2-methoxyphenyl and R5, R6, and R7 are H,).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07361656B2 |
| 出典データセット | uspto-grants-2008_04 |
| ORD ID | ord-fd194f83054845be845d9089738671af |
| 出典メモ | uspto-grants-2008_04 |