4-Chloropyridine → [2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethyl]-pyridin-4-yl-amine

HRID 901731

反応式

HRID 901731 の反応式
[Cl:1][C:2]1[CH:33]=[CH:32][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([N:13]3[CH:17]=[C:16]([C:18]4[CH:27]=[CH:26][C:21]([O:22][CH2:23][CH2:24][NH2:25])=[CH:20][CH:19]=4)[N:15]=[C:14]3[CH2:28][CH:29]([CH3:31])[CH3:30])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.Cl[C:35]1[CH:40]=[CH:39][N:38]=[CH:37][CH:36]=1>CN(C=O)C>[Cl:1][C:2]1[CH:33]=[CH:32][C:5]([O:6][C:7]2[CH:8]=[CH:9][C:10]([N:13]3[CH:17]=[C:16]([C:18]4[CH:27]=[CH:26][C:21]([O:22][CH2:23][CH2:24][NH:25][C:35]5[CH:40]=[CH:39][N:38]=[CH:37][CH:36]=5)=[CH:20][CH:19]=4)[N:15]=[C:14]3[CH2:28][CH:29]([CH3:30])[CH3:31])=[CH:11][CH:12]=2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 122884-ChloropyridineHCID 596992422-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethylamine

生成物 1

HCID 59699105[2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethyl]-pyridin-4-yl-amine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethylamine, the product of Example 512, was treated with 4-chloropyridine in DMF and was heated at 100° C. Aqueous workup and chromatography on silica gel afforded Example 519. (Yield: 80 mg)

後処理

  1. customAqueous workup and chromatography on silica gel afforded Example 519

出典と根拠

ORDレコード
ord-f0758d4cb2664e00a09e4d55d1c9077f
出典データセット
uspto-grants-2008_04
特許番号
US07361678B2

関連ノート

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