5-Fluoro-2-nitrophenol → Ethyl 2-(5-fluoro-2-nitrophenoxy)propanoate

HRID 901834

反応式

HRID 901834 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[OH:11])([O-:3])=[O:2].Br[CH:13]([CH3:19])[C:14]([O:16][CH2:17][CH3:18])=[O:15].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O.C(OCC)(=O)C>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[O:11][CH:13]([CH3:19])[C:14]([O:16][CH2:17][CH3:18])=[O:15])([O-:3])=[O:2]

参加物

6

反応物 3

HCID 99375-Fluoro-2-nitrophenolHCID 11430Potassium CarbonateHCID 79040Ethyl 2-bromopropionate

生成物 1

HCID 19786322Ethyl 2-(5-fluoro-2-nitrophenoxy)propanoate

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 2-nitro-5-fluorophenol (1.0 g, 1 eq, 6.36 mmol) and ethyl 2-bromopropionate (0.91 ml, 1.1 eq, 6.99 mmol) in dry acetone (32 ml) was added anhydrous potassium carbonate (2.63 g, 3 eq, 19.08 mmol) and the reaction mixture was refluxed for 16 h. The reaction mixture was filtered through celite and then condensed on rotavapour. The residue was diluted with ethyl acetate and washed with water and brine to yield ethyl 2-(2-nitro-5-fluorophenoxy)propanoate as crude compound (1.6 g, yield 98%), which was used in step (ii).

後処理

  1. temperaturethe reaction mixture was refluxed for 16 h
  2. filtrationThe reaction mixture was filtered through celite
  3. customcondensed on rotavapour
  4. washwashed with water and brine

出典と根拠

ORDレコード
ord-27d8f674a3af46f0ab0bc45109755fb1
出典データセット
uspto-grants-2008_04
特許番号
US07365064B2

関連ノート

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