Hydrochloric Acid → 3-(Piperidin-4-yl)propan-1-ol hydrochloride
反応式
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][CH2:9][OH:10])=[CH:3][CH:2]=1.[ClH:11]>[Pt]=O>[ClH:11].[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][CH2:9][OH:10])[CH2:3][CH2:2]1参加物
4
実験手順
1.00 g (7.29 mmol) of 4-pyridinepropanol was dissolved in 3N aqueous hydrochloric acid solution and 206 mg of platinum oxide was added thereto, followed by stirring of the mixture at room temperature under a hydrogen atmosphere at an ordinary pressure for 12 hours. The reaction mixture was filtered with Celite and the filtrate was distilled off under reduced pressure. The thus obtained residue was reprecipitated from methanol-ether to obtain 1.31 g (yield: quantitative) of the title compound as a white solid.
後処理
- filtrationThe reaction mixture was filtered with Celite
- distillationthe filtrate was distilled off under reduced pressure
- customThe thus obtained residue was reprecipitated from methanol-ether
出典と根拠
- ORDレコード
- ord-4b60620bf83045789194e22f531affcb
- 出典データセット
- uspto-grants-2008_04
- 特許番号
- US07365067B2
反応ノート
読み込み中…