Ethynylpyridine → 2-[(3,5-Dimethyl-1-cyclohexen-1-yl)ethynyl]pyridine

HRID 902077ノート

反応式

HRID 902077 の反応式
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1)#[CH:2].[CH3:9][CH:10]1[CH2:15][CH:14]([CH3:16])[CH2:13][C:12](=O)[CH2:11]1>>[CH3:9][CH:10]1[CH2:15][CH:14]([CH3:16])[CH2:13][C:12]([C:2]#[C:1][C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=2)=[CH:11]1

参加物

3

反応物 2

HCID 137268EthynylpyridineHCID 1375443,5-Dimethylcyclohexanone

生成物 1

HCID 98343262-[(3,5-Dimethyl-1-cyclohexen-1-yl)ethynyl]pyridine

実験手順

Reactants: 2-ethynylpyridine (6.0 mmol, 618 mg), 3,5-dimethylcyclohexanone (6.0 mmol, 0.85 mL); yields 2-[(3,5-dimethyl-1-cyclohexen-1-yl)ethynyl]pyridine as a transparent yellow oil (500 mg, 39% overall yield) as a mixture of diastereomers. 1H NMR (CDCl3, 300 MHz) 67 8.57 (m, 1H), 7.62 (m, 1H), 7.40 (m, 1H), 7.19 (m, 1H), 6.15 (br s, 1H), 2.29 (m, 2H), 1.80 (br m, (2H), 1.00 (m, 6H), 0.88 (br m, 2H). MS (EI ionization) 211 (M+).

出典と根拠

ORDレコード
ord-12b4b581055c4b2d9e6e9c640a19a65c
出典データセット
uspto-grants-2008_04
特許番号
US07365074B2

反応ノート

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