Benzylamine → 2-Amino-3-cyano-4-benzylaminoquinoline

HRID 902172ノート

反応式

HRID 902172 の反応式
[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH2:15]([NH2:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>O>[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10]([NH:22][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

参加物

4

反応物 2

HCID 7504BenzylamineHCID 114811212-Amino-3-cyano4-chloroquinoline

生成物 1

HCID 112888282-Amino-3-cyano-4-benzylaminoquinoline

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
130 °C

実験手順

5 g of 2-amino-3-cyano-4-chloroquinolin and 11 ml of benzylamine are heated under stirring at 130° C. The reaction mixture is poured onto 50 ml of water, the resulting precipitate is filtered off, washed with 50 ml of water. The pale-yellow precipitate is recrystallized from dimethylformamide to obtain 5.2 g of the title compound. Mp.: 206° C.

後処理

  1. filtrationthe resulting precipitate is filtered off
  2. washwashed with 50 ml of water
  3. customThe pale-yellow precipitate is recrystallized from dimethylformamide

出典と根拠

ORDレコード
ord-a2cf77d0c8cc42ad9a9e25edcf10163d
出典データセット
uspto-grants-2008_04
特許番号
US07365089B2

反応ノート

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