Acetyl chloride → 1-(2-Methoxy-benzylidene)-piperidinium chloride

反応式

[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:7][O:8][C:9]1[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=1[CH:11]=O.C([Cl:20])(=O)C>>[Cl-:20].[CH3:7][O:8][C:9]1[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=1[CH:11]=[N+:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

反応物 3

HCID 6367Acetyl chloride

HCID 8082Piperidine

HCID 86582-Methoxybenzaldehyde

生成物 1

HCID 179122761-(2-Methoxy-benzylidene)-piperidinium chloride

実験手順

The reaction of 18.4 g (0.216 mol) piperidine and 25.9 g (0.090 mol) 2-methoxybenzaldehyde in accordance with general synthesis instructions 2 and subsequent reaction with 5.3 ml (0.11 mol) acetyl chloride in accordance with general synthesis instructions 3 gave 13.4 g (corresponding to 62% of the yield calculated by theory) 1-(2-methoxy-benzylidene)-piperidinium chloride.