HCID 68965446、化合物 → HCID 69116794、化合物
反応式
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])[C:5]=1[OH:18])[CH:2]=[CH2:3]>C(Cl)Cl.CC1C=CC=CC=1[P](C1C=CC=CC=1C)([Pd](Cl)(Cl)[P](C1=C(C)C=CC=C1)(C1C=CC=CC=1C)C1C=CC=CC=1C)C1C=CC=CC=1C>[Cl:10][C:7]1[CH:8]=[CH:9][C:4]([CH:1]=[CH:2][CH3:3])=[C:5]([OH:18])[C:6]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH3:17]参加物
4
実験手順
To a solution of 3-allyl-6-chloro-2′-methylbiphenyl-2-ol (2.0 g, 7.7 mmol) in methylene chloride (70 mL) was added dichlorobis(acetonitrile)palladium (II) (0.22 g, 0.84 mmol). The resulting mixture was refluxed overnight. The solvent was removed under reduced pressure. Purification by ISCO using a solvent gradient of 5 to 20% ethyl acetate in hexanes provided 1.0 g (50%) of 6-chloro-2′-methyl-3-(prop-1-enyl)biphenyl-2-ol as a colorless oil.