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1-Bromo-2,4-dichlorobenzene → 2,4-Dichloro-6'-fluoro-2'-methoxy-biphenyl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Bromo-2,4-dichlorobenzene | HCID 70947 | — |
| 反応物 | (2-Fluoro-6-methoxyphenyl)boronic acid | HCID 3294524 | — |
| 溶媒 | Water 1,2-dimethoxyethane | HCID 18180031 | — |
| 生成物 | 2,4-Dichloro-6'-fluoro-2'-methoxy-biphenyl | HCID 69117451 | 63% |
反応手順
Treatment of 2,4-dichlorobromobenzene (13.8 g, 61.2 mmol) with 2-fluoro-6-methoxybenzene boronic acid (5.0 g, 29.4 mmol) in DME-water (5:1, 150 mL) according to the procedure described for Example 69, Step 1 provided 5.0 g (63%) of 2,4-dichloro-2′-fluoro-6′-methoxybiphenyl as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07365095B2 |
| 出典データセット | uspto-grants-2008_04 |
| ORD ID | ord-30feec0d3b7c448bae42df8bba8ac3bf |
| 出典メモ | uspto-grants-2008_04 |