Furan → 4-[4-(Furan-2-carbonyl)-piperazin-1-yl]-6-oxo-6,7-dihydro-thieno[2,3-b]-pyridine-5-carbonitrile
反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[CH:2]1.Cl[C:7]1[C:8]2[CH:18]=[CH:17][S:16][C:9]=2[NH:10][C:11](=[O:15])[C:12]=1[C:13]#[N:14].[O:19]1C=CC=[C:20]1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:20]([N:24]1[CH2:29][CH2:28][N:27]([C:7]2[C:8]3[CH:18]=[CH:17][S:16][C:9]=3[NH:10][C:11](=[O:15])[C:12]=2[C:13]#[N:14])[CH2:26][CH2:25]1)=[O:19]参加物
4
実験手順
To yield compounds of structure (III) wherein R2 is carbonitrile, R3 is furan, and R1 is as defined above, intermediate 4-chloro-6-oxo-6,7-dihydro-thieno[2,3-b]pyridine-5-carbonitrile, depicted by formula (50), was reacted with 1-(2-furyl)-piperazine to yield 4-[4-(furan-2-carbonyl)-piperazin-1-yl]-6-oxo-6,7-dihydro-thieno[2,3-b]-pyridine-5-carbonitrile, depicted by formula (52). This intermediate was either reacted with an appropriate halide (R1—X) or boronic acid (R1—B(OH)2) to yield target compounds of structure (III) with R2 as carbonitrile, R3 as furan, and R1 as defined above, as shown in Scheme 27.
出典と根拠
- ORDレコード
- ord-c44a93c34f4e4502a1007685c5212542
- 出典データセット
- uspto-grants-2008_04
- 特許番号
- US07365200B2
反応ノート
読み込み中…