N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propylamine → N-(2-Chloro-3-trifluoromethylbenzyl)-2-(4-chlorophenyl)propylamine

HRID 902732ノート

反応式

HRID 902732 の反応式
[Cl:1][C:2]1[C:20]([C:21]([F:24])([F:23])[F:22])=[CH:19][CH:18]=[CH:17][C:3]=1[CH2:4][NH:5][C:6](=O)[CH:7]([C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=1)[CH3:8].ClC1C(C(F)(F)F)=CC=CC=1CNCC(C1C=CC=CC=1Cl)C>>[Cl:1][C:2]1[C:20]([C:21]([F:24])([F:22])[F:23])=[CH:19][CH:18]=[CH:17][C:3]=1[CH2:4][NH:5][CH2:6][CH:7]([C:9]1[CH:10]=[CH:11][C:12]([Cl:15])=[CH:13][CH:14]=1)[CH3:8]

参加物

3

反応物 2

HCID 69252183N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propylamineHCID 69253466N-(2-chloro-3-trifluoromethylbenzyl)-2-(4-chlorophenyl)propionamide

生成物 1

HCID 69253913N-(2-Chloro-3-trifluoromethylbenzyl)-2-(4-chlorophenyl)propylamine収率 94%

実験手順

The titled compound was prepared from N-(2-chloro-3-trifluoromethylbenzyl)-2-(4-chlorophenyl)propionamide in 94% yield in the same manner as the preparation of N-(2-chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propylamine in Example 184c. MS (ESI) 362 (MH+).

出典と根拠

ORDレコード
ord-5741a9326ab14b7691e6bd20dc106603
出典データセット
uspto-grants-2008_04
特許番号
US07365085B2

反応ノート

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