2-(4-Methoxyphenyl)propan-1-amine → N-(2-Chloro-3-trifluoromethylbenzyl)-2-(4-methoxyphenyl)propylamine

HRID 902741

反応式

HRID 902741 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:12])[CH2:10][NH2:11])=[CH:5][CH:4]=1.[Cl:13][C:14]1[C:21]([C:22]([F:25])([F:24])[F:23])=[CH:20][CH:19]=[CH:18][C:15]=1[CH:16]=O.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>CO.CCOCC>[Cl:13][C:14]1[C:21]([C:22]([F:23])([F:24])[F:25])=[CH:20][CH:19]=[CH:18][C:15]=1[CH2:16][NH:11][CH2:10][CH:9]([C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)[CH3:12]

参加物

6

反応物 3

HCID 2026252-(4-Methoxyphenyl)propan-1-amineHCID 521998p-Toluenesulfonic acid monohydrateHCID 27366722-Chloro-3-(trifluoromethyl)benzaldehyde

生成物 1

HCID 69254854N-(2-Chloro-3-trifluoromethylbenzyl)-2-(4-methoxyphenyl)propylamine収率 77%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

A solution of 2-(4-methoxyphenyl)propylamine (183 mg, 1.11 mmole) and 2-chloro-3-trifluoromethylbenzaldehyde (230 mg, 1.11 mmole) in 10 mL of MeOH was treated with a crystal of p-toluenesulfonic acid hydrate, and stirred for 30 minutes. The reaction was diluted with Et2O, and washed with aqueous NaHCO3. The extracts were dried, and the solvent removed. A solution of the residue in 10 mL of MeOH was cooled to 0° and treated with excess NaBH4. The reaction was warmed to 23° and stirred for 30 minutes. The reaction was diluted with H2O and extracted with Et2O. The extracts were washed with H2O, dried and the solvent removed, and gave the titled compound, 305 mg (77% yield). MS (ESI) 358 (MH+)

後処理

  1. washwashed with aqueous NaHCO3
  2. customThe extracts were dried
  3. customthe solvent removed
  4. temperatureA solution of the residue in 10 mL of MeOH was cooled to 0°
  5. additiontreated with excess NaBH4
  6. temperatureThe reaction was warmed to 23°
  7. stirringstirred for 30 minutes
  8. additionThe reaction was diluted with H2O
  9. extractionextracted with Et2O
  10. washThe extracts were washed with H2O
  11. customdried
  12. customthe solvent removed

出典と根拠

ORDレコード
ord-186c9854a9884c8eb685c624d6261659
出典データセット
uspto-grants-2008_04
特許番号
US07365085B2

関連ノート

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