Methyl 4-[4-(chloromethyl)-1,3-thiazol-2-yl]benzoate → 4-[4-(Chloromethyl)-1,3-thiazol-2-yl]benzoic acid
反応式
[Cl:1][CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14]C)=[O:13])=[CH:10][CH:9]=2)[S:6][CH:7]=1>Cl>[Cl:1][CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:12]([OH:14])=[O:13])=[CH:16][CH:17]=2)[S:6][CH:7]=1参加物
3
実験手順
An aqueous solution of HCl (6N, 200 mL) was added to methyl 4-[4-(chloromethyl)-1,3-thiazol-2-yl]benzoate (20.0 g, 0.075 mol) and refluxed overnight. The reaction mixture was allowed to cool to ambient temperatures and the solid was filtered and then dried in vacuo at 40° C. to give the title compound (15.0 g, 75%).
後処理
- temperaturerefluxed overnight
- temperatureto cool to ambient temperatures
- filtrationthe solid was filtered
- customdried in vacuo at 40° C.
出典と根拠
- ORDレコード
- ord-838eed514c4e41c08fac337aa0623775
- 出典データセット
- uspto-grants-2008_04
- 特許番号
- US07365225B2
反応ノート
読み込み中…