4-(Trifluoromethyl)benzoyl chloride → [4-({{[2-(4-{[(4-Pentylbenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}[4-(trifluoromethyl)benzoyl]amino}methyl)phenoxy]acetic acid

HRID 902813ノート

反応式

HRID 902813 の反応式
[CH2:1]([C:6]1[CH:13]=[CH:12][C:9]([CH2:10][NH2:11])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5].Cl[CH2:15][C:16]1[N:17]=[C:18]([C:21]2[CH:29]=[CH:28][C:24]([C:25](Cl)=[O:26])=[CH:23][CH:22]=2)[S:19][CH:20]=1.[F:30][C:31]([F:42])([F:41])[C:32]1[CH:40]=[CH:39][C:35]([C:36](Cl)=[O:37])=[CH:34][CH:33]=1.C[O:44][C:45](=[O:56])[CH2:46][O:47][C:48]1[CH:53]=[CH:52][C:51]([CH2:54][NH2:55])=[CH:50][CH:49]=1>>[CH2:1]([C:6]1[CH:13]=[CH:12][C:9]([CH2:10][NH:11][C:25]([C:24]2[CH:28]=[CH:29][C:21]([C:18]3[S:19][CH:20]=[C:16]([CH2:15][N:55]([CH2:54][C:51]4[CH:52]=[CH:53][C:48]([O:47][CH2:46][C:45]([OH:56])=[O:44])=[CH:49][CH:50]=4)[C:36](=[O:37])[C:35]4[CH:39]=[CH:40][C:32]([C:31]([F:42])([F:41])[F:30])=[CH:33][CH:34]=4)[N:17]=3)=[CH:22][CH:23]=2)=[O:26])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5]

参加物

5

反応物 4

HCID 676074-(Trifluoromethyl)benzoyl chlorideHCID 2775785(4-Pentylphenyl)methanamineHCID 16770770Methyl [4-(aminomethyl)phenoxy]acetateHCID 586936994-[4-(Chloromethyl)-1,3-thiazol-2-yl]benzoyl chloride

生成物 1

HCID 11354604[4-({{[2-(4-{[(4-Pentylbenzyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}[4-(trifluoromethyl)benzoyl]amino}methyl)phenoxy]acetic acid

実験手順

The title compound was prepared following the procedure A using 4-pentylbenzylamine, 4-[4-(chloromethyl)-1,3-thiazol-2-yl]benzoyl chloride, 4-(trifluoromethyl)benzoyl chloride and methyl[4-(aminomethyl)phenoxy]acetate, acetate salt. M+(ESI): 730

出典と根拠

ORDレコード
ord-cce7ea327b6c4fccbfe59ea89a28e71f
出典データセット
uspto-grants-2008_04
特許番号
US07365225B2

反応ノート

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