Benzenepropanoyl chloride → (4-{[{[2-(4-{[(4-Phenylbutyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}(3-phenylpropanoyl)amino]methyl}phenoxy)acetic acid

HRID 902816ノート

反応式

HRID 902816 の反応式
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][NH2:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[CH2:13][C:14]1[N:15]=[C:16]([C:19]2[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=2)[S:17][CH:18]=1.[C:28]1([CH2:34][CH2:35][C:36](Cl)=[O:37])[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.C[O:40][C:41](=[O:52])[CH2:42][O:43][C:44]1[CH:49]=[CH:48][C:47]([CH2:50][NH2:51])=[CH:46][CH:45]=1>>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:23]([C:22]2[CH:26]=[CH:27][C:19]([C:16]3[S:17][CH:18]=[C:14]([CH2:13][N:51]([CH2:50][C:47]4[CH:48]=[CH:49][C:44]([O:43][CH2:42][C:41]([OH:52])=[O:40])=[CH:45][CH:46]=4)[C:36](=[O:37])[CH2:35][CH2:34][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[N:15]=3)=[CH:20][CH:21]=2)=[O:24])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 4

HCID 64801Benzenepropanoyl chlorideHCID 83242BenzenebutanamineHCID 16770770Methyl [4-(aminomethyl)phenoxy]acetateHCID 586936994-[4-(Chloromethyl)-1,3-thiazol-2-yl]benzoyl chloride

生成物 1

HCID 11365843(4-{[{[2-(4-{[(4-Phenylbutyl)amino]carbonyl}phenyl)-1,3-thiazol-4-yl]methyl}(3-phenylpropanoyl)amino]methyl}phenoxy)acetic acid

実験手順

The title compound was prepared following the procedure Λ using 4-phenylbutylamine, 4-[4-(chloromethyl)-1,3-thiazol-2-yl]benzoyl chloride, 3-phenylpropanoyl chloride and methyl[4-(aminomethyl)phenoxy]acetate, acetate salt. M+(ESI): 662.1

出典と根拠

ORDレコード
ord-83c5e9e244084f5997e00888ec61a142
出典データセット
uspto-grants-2008_04
特許番号
US07365225B2

反応ノート

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