化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → Methyl 3-methoxy-2-(methoxymethyl)propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 2-Propenoic acid, 2-(bromomethyl)-, methyl ester | HCID 521093 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Methyl 3-methoxy-2-(methoxymethyl)propanoate | HCID 22934772 | — |
反応手順
Sodium methoxide (1.21 g) was added to a solution of methyl 2-(bromomethyl)acrylate (1.0 ml) in methanol (10 ml), and the mixture was heated under reflux for 26 hours. After cooling, the reaction mixture was diluted with diethyl ether, and precipitate was collected by filtration and the filtrate was concentrated under reduced pressure. The resultant residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:4) to obtain the title compound (726 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07365205B2 |
| 出典データセット | uspto-grants-2008_04 |
| ORD ID | ord-2380bbf5a74c4fafaa8e79e6e211fbcd |
| 出典メモ | uspto-grants-2008_04 |