2-Chloroethyl N-(2-chloro-4-nitrophenyl)carbamate → 3-(2-Chloro-4-nitrophenyl)-2-oxazolidinone

HRID 902999ノート

反応式

HRID 902999 の反応式
C[O-].[Na+].[Cl:4][C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:6]=1[NH:14][C:15](=[O:20])[O:16][CH2:17][CH2:18]Cl>CO.C(O)C>[Cl:4][C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:6]=1[N:14]1[CH2:18][CH2:17][O:16][C:15]1=[O:20]

参加物

5

反応物 2

HCID 3107132-Chloroethyl N-(2-chloro-4-nitrophenyl)carbamateHCID 10942334Sodium Methoxide

生成物 1

HCID 233373183-(2-Chloro-4-nitrophenyl)-2-oxazolidinone

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 887Methanol溶媒

実験手順

A solution of 11.25 g of sodium methoxide in 50 ml of methanol was added drop-by-drop to a stirred solution of 58.0 g of 1A in 400 ml of ethanol. The mixture was refluxed for 5 minutes, then the volatile materials were evaporated under reduced pressure. The residue was treated with water and extracted with ether. The extract was dried and concentrated under reduced pressure. The residue was cooled and filtered to give 3-(2-chloro-4-nitrophenyl)-2-oxazolidinone (1B), as a white solid, mp: 94°-96° C.

後処理

  1. temperatureThe mixture was refluxed for 5 minutes
  2. customthe volatile materials were evaporated under reduced pressure
  3. additionThe residue was treated with water
  4. extractionextracted with ether
  5. customThe extract was dried
  6. concentrationconcentrated under reduced pressure
  7. temperatureThe residue was cooled
  8. filtrationfiltered

出典と根拠

ORDレコード
ord-0347dc0460dd46d2895dd2d891fb1b40
出典データセット
uspto-grants-1980_10
特許番号
US04226612

反応ノート

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