N-methoxy-N-methylcarbamoyl chloride → N'-(3-chloro-4-(2-oxo-3-oxazolidinyl)phenyl)-N-methoxy-N-methylurea

HRID 903001ノート

反応式

HRID 903001 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][O:10][C:9]2=[O:13])=[C:4]([Cl:14])[CH:3]=1.[CH3:15][O:16][N:17]([CH3:21])[C:18](Cl)=[O:19]>C(N(CC)CC)C>[Cl:14][C:4]1[CH:3]=[C:2]([NH:1][C:18](=[O:19])[N:17]([O:16][CH3:15])[CH3:21])[CH:7]=[CH:6][C:5]=1[N:8]1[CH2:12][CH2:11][O:10][C:9]1=[O:13]

参加物

4

反応物 2

HCID 2734926N-methoxy-N-methylcarbamoyl chlorideHCID 233373153-(4-Amino-2-chlorophenyl)-2-oxazolidinone

生成物 1

HCID 23337319N'-(3-chloro-4-(2-oxo-3-oxazolidinyl)phenyl)-N-methoxy-N-methylurea

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

10.1 g of triethyamine was added to the solution of 1C, then 13.6 g of N-methoxy-N-methylcarbamoyl chloride was added drop-by-drop. After 12 hours at room temperature, the mixture was washed with water and extracted with ether. The extract was dried and the ether was evaporated under reduced pressure. The residue was chromatographed over silica gel to give 1, as a white solid, mp: 151°-153° C.

後処理

  1. washthe mixture was washed with water
  2. extractionextracted with ether
  3. customThe extract was dried
  4. customthe ether was evaporated under reduced pressure
  5. customThe residue was chromatographed over silica gel
  6. customto give 1

出典と根拠

ORDレコード
ord-be16dce8df8346fbb304bce5a1408b3f
出典データセット
uspto-grants-1980_10
特許番号
US04226612

反応ノート

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