Hydrochloric Acid → HCID 15313948、化合物

HRID 903116ノート

反応式

HRID 903116 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][CH:13]([CH:17]([CH3:19])[CH3:18])[C:14](N)=[O:15].Cl.[C:21](=O)(O)[O-:22].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][CH:13]([CH:17]([CH3:19])[CH3:18])[C:14]([O:22][CH3:21])=[O:15]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 233376972-(2-Chloro-4-trifluoromethylphenylamino)-3-methylbutyramide

生成物 1

HCID 15313948HCID 15313948、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutyramide (1 mmol) and 4 ml of methanol, saturated with HCl gas, is heated at 75° for about 40 hours. The mixture is cooled, poured into saturated aqueous sodium bicarbonate and extracted with ether. The combined ether extracts are dried over sodium sulfate and solvent removed in vacuo to yield methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, which can be further purified by prep. thin layer chromatography.

後処理

  1. temperatureThe mixture is cooled
  2. extractionextracted with ether
  3. dry with materialThe combined ether extracts are dried over sodium sulfate and solvent
  4. customremoved in vacuo

出典と根拠

ORDレコード
ord-4eef25e6ba7e4adaa88d56cebb91a18c
出典データセット
uspto-grants-1980_10
特許番号
US04226802

反応ノート

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