Methyl Isocyanate → Fluzinamide

HRID 903132ノート

反応式

HRID 903132 の反応式
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[O:6][CH:7]1[CH2:10][NH:9][CH2:8]1.[CH3:16][N:17]=[C:18]=[O:19]>C1C=CC=CC=1>[CH3:16][NH:17][C:18]([N:9]1[CH2:10][CH:7]([O:6][C:5]2[CH:11]=[CH:12][CH:13]=[C:3]([C:2]([F:1])([F:14])[F:15])[CH:4]=2)[CH2:8]1)=[O:19]

参加物

4

反応物 2

HCID 12228Methyl IsocyanateHCID 111385383-[3-(Trifluoromethyl)phenoxy]azetidine

生成物 1

HCID 53467Fluzinamide

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

To 6.0 g. (0.024 mole) of 3-(3-trifluoromethylphenoxy) azetidine in 50 ml. of dry benzene was added dropwise 1.37 g. (0.024 mole) of methylisocyanate with stirring, and stirring was continued for 30 minutes. The solid which crystallized in the flask was recrystallized using 95% ethanol to give 5.0 g. (76%) of product (m.p. 145°-147° C.).

後処理

  1. customThe solid which crystallized in the flask
  2. customwas recrystallized
  3. customto give 5.0 g

出典と根拠

ORDレコード
ord-868b300370dd4c3f90fca1ffe2ead79d
出典データセット
uspto-grants-1980_10
特許番号
US04226861

反応ノート

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