Methyl Isocyanate → N-Methyl 3-(3-aminocarbonylphenoxy)-1-azetidinecarboxamide
反応式
[NH:1]1[CH2:4][CH:3]([O:5][C:6]2[CH:7]=[C:8]([CH:12]=[CH:13][CH:14]=2)[C:9]([NH2:11])=[O:10])[CH2:2]1.[CH3:15][N:16]=[C:17]=[O:18]>C1C=CC=CC=1>[CH3:15][NH:16][C:17]([N:1]1[CH2:4][CH:3]([O:5][C:6]2[CH:14]=[CH:13][CH:12]=[C:8]([C:9]([NH2:11])=[O:10])[CH:7]=2)[CH2:2]1)=[O:18]参加物
4
実験手順
To a stirring solution of 7.0 g. (0.036 mole) of 3-(3-azetidinyloxy)benzamide in 75 ml. of dry benzene was slowly added 2.0 g. (0.036 mole) of methylisocyanate. Stirring was continued at room temperature for one hour. The solid which separated was filtered and recrystallized from 60% ethanol. The product weighed 6.0 g. (67%) and melted at 238°-240° C.
後処理
- customThe solid which separated
- filtrationwas filtered
- customrecrystallized from 60% ethanol
出典と根拠
- ORDレコード
- ord-ef6347e3bf174c59a1cc80fab2a4d170
- 出典データセット
- uspto-grants-1980_10
- 特許番号
- US04226861
反応ノート
読み込み中…