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Hydrochloric Acid → 7-Chloro-10-[(4-dimethylaminobutyl)amino]-2-methoxypyrido[3,2-b]quinoline dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Phenol | HCID 996 | — |
| 反応物 | 1-Aza-6,9-dichloro-2-methoxyacridine | HCID 23107 | — |
| 反応物 | 4-Dimethylaminobutylamine | HCID 77063 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 7-Chloro-10-[(4-dimethylaminobutyl)amino]-2-methoxypyrido[3,2-b]quinoline dihydrochloride | HCID 23337809 | — |
反応手順
A mixture of 4.2 g. of 7,10-dichloro-2-methoxypyrido [3,2-b]quinoline, 1.6 g. of dimethylaminobutylamine and 10 g. of phenol is stirred and heated on a steam bath for 3 hours. The reaction is cooled, 30 ml. of ethanol is added and this mixture is poured into a mixture of 300 ml. of acetone and 3.75 ml. of concentrated hydrochloric acid. The yellow precipitate is collected, washed with acetone, air-dried and recrystallized from 100 ml. of 95% alcohol giving the desired product as yellow crystals, mp. 237°-238° C. (dec.)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04226869 |
| 出典データセット | uspto-grants-1980_10 |
| ORD ID | ord-08a98d10d55740a6baee2dbe2b59e400 |
| 出典メモ | uspto-grants-1980_10 |