Hydrochloric Acid → Ethyl-1-hydroxy-1,2,3,4-tetrahydronaphthalene-1-carboximidate
反応式
[C:1]([C:3]1([OH:13])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5][CH2:4]1)#[N:2].Cl.[CH2:15]([OH:17])[CH3:16]>>[CH2:15]([O:17][C:1]([C:3]1([OH:13])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH2:5][CH2:4]1)=[NH:2])[CH3:16]参加物
4
実験手順
The cyanohydrin of Example 4 (6.0 g, 34.7 mmol) was dissolved in 60 ml ethanol and perfused with hydrogen chloride for 30 minutes. After a 16 hour reaction period at 0° C. the mixture was evaporated in vacuo to a solid which was triturated with ether. The residue was taken up in 200 ml chloroform and washed with 2×50 ml saturated sodium bicarbonate, 1×50 ml brine, dried over sodium sulfate, filtered, and concentrated to a solid; 5.3 g (71%), mp 84°-86° C.
後処理
- customAfter a 16 hour reaction period at 0° C. the mixture
- customwas evaporated in vacuo to a solid which
- customwas triturated with ether
- washwashed with 2×50 ml saturated sodium bicarbonate, 1×50 ml brine
- dry with materialdried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated to a solid
出典と根拠
- ORDレコード
- ord-44d53ec7784b4f6eaf07330e6bf7f557
- 出典データセット
- uspto-grants-1980_10
- 特許番号
- US04226875
反応ノート
読み込み中…