Ethanol → Ethyl 3-(6-methylpyridin-3-yl)prop-2-enoate
反応式
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]([OH:12])=[O:11])=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH2:18](O)[CH3:19]>>[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]([O:12][CH2:18][CH3:19])=[O:11])=[CH:4][CH:3]=1参加物
4
実験手順
A stirred mixture of 3-(6-methyl-3-pyridyl)acrylic acid (50.70 g), dry ethanol (350 ml) and concentrated sulphuric acid (25 ml) was heated under reflux for 18 hours and ethanol (~250 ml) was removed by evaporation. The residue was poured into ice-aqueous ammonia and the mixture was extracted with ether. The ether extracts were washed with water and evaporated to an oil which crystallised on standing to give ethyl 3-(6-methyl-3-pyridyl)acrylate, m.p. 36°-37°.
後処理
- temperaturewas heated
- temperatureunder reflux for 18 hours
- customethanol (~250 ml) was removed by evaporation
- additionThe residue was poured into ice-aqueous ammonia
- extractionthe mixture was extracted with ether
- washThe ether extracts were washed with water
- customevaporated to an oil which
- customcrystallised
出典と根拠
- ORDレコード
- ord-bb4087bcc6c442458a4c6f43ed55dee8
- 出典データセット
- uspto-grants-1980_10
- 特許番号
- US04227000
反応ノート
読み込み中…