2-Pentanamine → N-(1-methylbutyl)-4-(methylsulfonyl)-2,6-dinitro-m-toluidine

HRID 903483

反応式

HRID 903483 の反応式
Cl[C:2]1[C:3]([N+:16]([O-:18])=[O:17])=[C:4]([CH3:15])[C:5]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[NH2:19][CH:20]([CH2:22][CH2:23][CH3:24])[CH3:21]>C1C=CC=CC=1>[CH3:21][CH:20]([NH:19][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([S:11]([CH3:14])(=[O:13])=[O:12])=[C:4]([CH3:15])[C:3]=1[N+:16]([O-:18])=[O:17])[CH2:22][CH2:23][CH3:24]

参加物

4

反応物 2

HCID 122462-PentanamineHCID 23335973HCID 23335973、化合物

生成物 1

HCID 23335968N-(1-methylbutyl)-4-(methylsulfonyl)-2,6-dinitro-m-toluidine

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A mixture of 3-chloro-6-(methylsulfonyl)-2,4-di-nitrotoluene (10.0 g., 0.034 mole) and 2-aminopentane (6.1 g. 0.07 mole) is refluxed in benzene (75 ml.) for 4 hours. After standing overnight, the mixture is successively washed with dilute hydrochloric acid, water, a 5% aqueous potassium carbonate solution and finally water. The mixture is then dried over magnesium sulfate. Removal of the magnesium sulfate and solvent leaves the desired product as a yellow oil which readily crystallized on cooling. The crude product is recrystallized from ethanol to give 9.5 grams with m.p. 85°-88° C.

後処理

  1. washthe mixture is successively washed with dilute hydrochloric acid, water
  2. dry with materialThe mixture is then dried over magnesium sulfate
  3. customRemoval of the magnesium sulfate and solvent

出典と根拠

ORDレコード
ord-894ae7259c644d92a7d8c2883be4ed37
出典データセット
uspto-grants-1980_10
特許番号
US04227913

関連ノート

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