Hydrochloric Acid → 7-Fluorosulfonyl-1,2,3,4-tetrahydroisoquinoline hydrochloride
反応式
FC(F)(F)C([N:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][C:9]([S:15]([F:18])(=[O:17])=[O:16])=[CH:10][CH:11]=2)[CH2:6]1)=O.[ClH:21]>CC(C)=O>[ClH:21].[F:18][S:15]([C:9]1[CH:8]=[C:7]2[C:12]([CH2:13][CH2:14][NH:5][CH2:6]2)=[CH:11][CH:10]=1)(=[O:16])=[O:17]参加物
4
実験手順
A solution of 5.0 g. (0.06 mole) of 2-trifluoroacetyl-7-fluorosulfonyl-1,2,3,4-tetrahydroisoquinoline and 100 ml. of acetone and 50 ml. of 6 N hydrochloric acid was stirred at room temperature overnight. The solution was concentrated, taken up in water, extracted with chloroform, concentrated and the water azeotropically removed. The resultant solid was recrystallized from methanol to give 7-fluorosulfonyl-1,2,3,4-tetrahydroisoquinoline hydrochloride, m.p. 230°-232° C.
後処理
- concentrationThe solution was concentrated
- extractionextracted with chloroform
- concentrationconcentrated
- customthe water azeotropically removed
- customThe resultant solid was recrystallized from methanol
出典と根拠
- ORDレコード
- ord-c017c1a3a71e4b15b3a92f775cf983fd
- 出典データセット
- uspto-grants-1980_10
- 特許番号
- US04228170
反応ノート
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