Dimethylamine → [(2-Bromo-phenyl)-(4-nitro-1H-indol-3-yl)-methyl]-dimethyl-amine

反応式

[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]=[CH:7][NH:8]2)([O-:3])=[O:2].[Cl-].[Br:14][C:15]1[CH:24]=[CH:23][CH:22]=[CH:21][C:16]=1[CH:17]=[N+:18]([CH3:20])[CH3:19].BrC1C=CC=CC=1C=O.CNC>>[Br:14][C:15]1[CH:24]=[CH:23][CH:22]=[CH:21][C:16]=1[CH:17]([N:18]([CH3:20])[CH3:19])[C:6]1[C:5]2[C:9](=[CH:10][CH:11]=[CH:12][C:4]=2[N+:1]([O-:3])=[O:2])[NH:8][CH:7]=1

参加物

反応物 4

HCID 674Dimethylamine

HCID 811292-Bromobenzaldehyde

HCID 1457664-Nitro-1H-indole

HCID 21985380(2-Bromo-benzylidene)-dimethyl-ammonium chloride

生成物 1

HCID 21985350[(2-Bromo-phenyl)-(4-nitro-1H-indol-3-yl)-methyl]-dimethyl-amine

実験手順

The preparation was carried out in accordance with general synthesis instructions 4 from 4-nitroindole and (2-bromo-benzylidene)-dimethyl-ammonium chloride, which had been prepared in accordance with example 24 from 2-bromo-benzaldehyde and dimethylamine.