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Methyltryptamine → 1,2,3,4-Tetrahydro-1-[3,3-bis(ethoxycarbonyl)-propyl]-2-methyl-beta-carboline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyltryptamine | HCID 6088 | — |
| 反応物 | Diethyl (3-oxopropyl)malonate | HCID 88096 | — |
| 生成物 | 1,2,3,4-Tetrahydro-1-[3,3-bis(ethoxycarbonyl)-propyl]-2-methyl-beta-carboline | HCID 23336481 | 55.2% |
反応手順
1.78 g of N-methyl-tryptamine (i.e., 3-(2-methylaminoethyl)-indole) and 3.1 g of 4,4-bis(ethoxycarbonyl)-butanal were treated in the same manner as described in Example 21-(1). 2.1 g of 1,2,3,4-tetrahydro-1-[3,3-bis-(ethoxycarbonyl)propyl]-2-methyl-β-carboline were thereby obtained. Yield: 55.0%
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04228168 |
| 出典データセット | uspto-grants-1980_10 |
| ORD ID | ord-50ab92d2f9754825bd25d8207a0fbca9 |
| 出典メモ | uspto-grants-1980_10 |