Methane → 1,2,3,4-Tetrahydro-1-(3-carboxypropyl)-2-methyl-beta-carboline hydrochloride
反応式
[ClH:1].C([O:4][C:5]([CH:7](C(OCC)=O)[CH2:8][CH2:9][CH:10]1[C:22]2[NH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:14]=2[CH2:13][CH2:12][N:11]1[CH3:23])=[O:6])C.C>>[ClH:1].[C:5]([CH2:7][CH2:8][CH2:9][CH:10]1[C:22]2[NH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:14]=2[CH2:13][CH2:12][N:11]1[CH3:23])([OH:6])=[O:4]参加物
4
反応条件
- 温度
- 80 °C
実験手順
25 ml of 5% hydrochloric acid were added to 1.08 g of 1,2,3,4-tetrahydro-1-[3,3-bis(ethoxycarbonyl)-propyl]-2-methyl-β-carboline, and the mixture was stirred at 80° C. for 5 hours. After the reaction was completed, the mixture was treated with activated charcoal powder and then condensed under reduced pressure. 930 mg of 1,2,3,4-tetrahydro-1-(3-carboxypropyl)-2-methyl-β-carboline hydrochloride were thereby obtained. Yield: 79.8%
後処理
- customcondensed under reduced pressure
出典と根拠
- ORDレコード
- ord-4ab9576b60004be88b9a0218d5532cfa
- 出典データセット
- uspto-grants-1980_10
- 特許番号
- US04228168
反応ノート
読み込み中…