2-Oxoadipic acid → 1,2,3,4-Tetrahydro-1-carboxy-1-(3-carboxypropyl)-2-ethyl-beta-carboline

HRID 903604

反応式

HRID 903604 の反応式
[CH2:1]([NH:3][CH2:4][CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][CH:7]=1)[CH3:2].O=[C:16]([CH2:20][CH2:21][CH2:22][C:23]([OH:25])=[O:24])[C:17]([OH:19])=[O:18]>C1C=CC=CC=1.O1CCOCC1>[C:17]([C:16]1([CH2:20][CH2:21][CH2:22][C:23]([OH:25])=[O:24])[C:7]2[NH:8][C:9]3[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=3)[C:6]=2[CH2:5][CH2:4][N:3]1[CH2:1][CH3:2])([OH:19])=[O:18]

参加物

5

反応物 2

HCID 712-Oxoadipic acidHCID 6092N-Ethyltryptamine

生成物 1

HCID 233365071,2,3,4-Tetrahydro-1-carboxy-1-(3-carboxypropyl)-2-ethyl-beta-carboline収率 40%

試薬・触媒・溶媒 2

HCID 241Benzene溶媒HCID 312751,4-Dioxane溶媒

実験手順

5 g of N-ethyl-tryptamine (i.e., 3-(2-ethylaminoethyl)-indole) were dissolved in 100 ml of absolute benzene, and a solution of 4.70 g of α-keto-adipic acid in 50 ml of absolute dioxane was added thereto at room temperature. The mixture was refluxed for 20 hours. After the reaction was completed, the mixture was evaporated to remove solvent. The residue thus obtained was recrystallized from ethanol, whereby 3.51 g of 1,2,3,4-tetrahydro-1-carboxy-1-(3-carboxypropyl)-2-ethyl-β-carboline were obtained. Yield: 38.0%

後処理

  1. customat room temperature
  2. temperatureThe mixture was refluxed for 20 hours
  3. customthe mixture was evaporated
  4. customto remove solvent
  5. customThe residue thus obtained
  6. customwas recrystallized from ethanol

出典と根拠

ORDレコード
ord-82daf5f83fa549d59bd1c96c58e2bfd8
出典データセット
uspto-grants-1980_10
特許番号
US04228168

関連ノート

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