Ethylamine → HCID 178464569、化合物

HRID 903692ノート

反応式

HRID 903692 の反応式
[CH2:1]([NH2:3])[CH3:2].[C:4]([NH:6][C:7](=[N:10][CH2:11][CH2:12][S:13][CH2:14][C:15]1[NH:19][CH:18]=[N:17][C:16]=1[CH3:20])SC)#[N:5]>C(O)C>[C:4]([NH:6][C:7]([NH:3][CH2:1][CH3:2])=[N:10][CH2:11][CH2:12][S:13][CH2:14][C:15]1[NH:19][CH:18]=[N:17][C:16]=1[CH3:20])#[N:5]

参加物

4

反応物 2

HCID 6341EthylamineHCID 178503877HCID 178503877、化合物

生成物 1

HCID 178464569HCID 178464569、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Anhydrous ethylamine (9.0 g.) was added to a solution of N-cyano-N-'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-S-methylisothiourea (Example 3(c). 5.0 g.) in ethanol. The solution was heated under reflux for 8 hours and concentrated under reduced pressure. The residue was dissolved in isopropyl alcohol, filtered, and diluted with water. The white solid obtained was recrystallised from isopropyl alcohol-ether to yield N-cyano-N'-ethyl-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine. m.p. 118°-120°. (Found: C, 49.6; H, 6.8; N, 31.2 S. 11.7. C11H18N6S requires: C, 49.6; H, 6.8; N, 31.6; S, 12.0).

後処理

  1. temperatureThe solution was heated
  2. temperatureunder reflux for 8 hours
  3. concentrationconcentrated under reduced pressure
  4. dissolutionThe residue was dissolved in isopropyl alcohol
  5. filtrationfiltered
  6. additiondiluted with water
  7. customThe white solid obtained
  8. customwas recrystallised from isopropyl alcohol-ether

出典と根拠

ORDレコード
ord-fa29bdf3bde5493ebedc1a4e80327465
出典データセット
uspto-grants-1980_10
特許番号
US04228291

反応ノート

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