Acetic Acid → 2-[3-(3-Trifluoromethylphenyl)-5-Isoxazolyl]Benzoic Acid
反応式
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([C:9]2[CH:13]=[C:12]([C:14]3[CH:23]=[CH:22][CH:21]=[CH:20][C:15]=3[C:16]([O:18]C)=[O:17])[O:11][N:10]=2)[CH:6]=[CH:7][CH:8]=1.C(O)(=O)C.Cl>O>[F:25][C:2]([F:1])([F:24])[C:3]1[CH:4]=[C:5]([C:9]2[CH:13]=[C:12]([C:14]3[CH:23]=[CH:22][CH:21]=[CH:20][C:15]=3[C:16]([OH:18])=[O:17])[O:11][N:10]=2)[CH:6]=[CH:7][CH:8]=1参加物
5
実験手順
A solution of 6.20 g of methyl 2-[3-(3-trifluoromethylphenyl)-5-isoxazolyl]benzoate, 75 ml. of acetic acid, and 50 ml. of concentrated HCl was held at reflux for 4 hours, cooled, and poured into 450 ml. of cold water. The resultant solid was recrystallized from CH3CN to give 3.87 g of solid, mp 176°-177° C.