Peracetic Acid → HCID 19010447、化合物
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[O:5][C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1.C(OO)(=[O:17])C>C(O)(=O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[O:5][C:6]1[CH:7]=[N+:8]([O-:17])[CH:9]=[CH:10][CH:11]=1参加物
4
実験手順
A solution of 32 g of 3-(3-fluorophenoxy)pyridine [Fr. Pat. No. 1,472,619 (1967)] in 50 ml of glacial acetic acid is treated with 35 g of 40% peracetic acid in acetic acid and the mixture is refluxed 16 hours. The mixture is concentrated at reduced pressure and the oil is dissolved in 250 ml of dichloromethane. The dichloromethane solution is washed with excess 10% sodium hydroxide solution. The solution is dried and concentrated to dryness to yield 3-(3-fluorophenoxy)pyridine 1-oxide, m.p. 63°-66° C.
後処理
- temperaturethe mixture is refluxed 16 hours
- concentrationThe mixture is concentrated at reduced pressure
- dissolutionthe oil is dissolved in 250 ml of dichloromethane
- washThe dichloromethane solution is washed with excess 10% sodium hydroxide solution
- customThe solution is dried
- concentrationconcentrated to dryness
出典と根拠
- ORDレコード
- ord-83e20b08ca0448669fb98d659cc7192b
- 出典データセット
- uspto-grants-1980_10
- 特許番号
- US04229457
反応ノート
読み込み中…