Water → HCID 21782073、化合物

HRID 903888

反応式

HRID 903888 の反応式
[CH2:1]([C:3]1([C:8]([OH:10])=[O:9])[NH:7][CH2:6][CH2:5][S:4]1)[CH3:2].O.[C:12](=O)(O)[O-].[Na+]>Cl.CO>[CH3:12][O:9][C:8]([C:3]1([CH2:1][CH3:2])[NH:7][CH2:6][CH2:5][S:4]1)=[O:10]

参加物

5

反応物 3

HCID 962WaterHCID 198462Thiazolidinecarboxylic acid, 2-ethyl-HCID 516892Sodium Bicarbonate

生成物 1

HCID 21782073HCID 21782073、化合物収率 18.4%

試薬・触媒・溶媒 1

HCID 21893726Hydrochloride methanol溶媒

実験手順

10.0 g of the 2-ethyl-thiazolidine-2-carboxylic acid thus obtained was dissolved in 200 ml of 20% hydrogen chloride-methanol solution. After being refluxed for 30 minutes, the reaction mixture was concentrated under reduced pressure to afford a residue, to which was added water, and was then neutralized with an aqueous saturated solution of sodium bicarbonate. Upon extracting with ethyl acetate, the extract was chromatographed on a column of silica gel to give 2.0 g (yield 18.4%) of 2-ethyl-thiazolidine-2-carboxylic acid methyl ester with a reflex index of nD26 1.501.

後処理

  1. temperatureAfter being refluxed for 30 minutes
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. customto afford a residue
  4. extractionUpon extracting with ethyl acetate
  5. customthe extract was chromatographed on a column of silica gel

出典と根拠

ORDレコード
ord-49855af150524eecbe110a1c074cd2b8
出典データセット
uspto-grants-1980_10
特許番号
US04229461

関連ノート

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