Acetic Anhydride → 1-Acetyl-3-cyano-4-phenylpyrrole
反応式
[C:1]([C:3]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][NH:5][CH:4]=1)#[N:2].[C:14](OC(=O)C)(=[O:16])[CH3:15]>O>[C:14]([N:5]1[CH:6]=[C:7]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:3]([C:1]#[N:2])=[CH:4]1)(=[O:16])[CH3:15]参加物
4
実験手順
4 g of 3-cyano-4-phenylpyrrole (Compound No. 8) was added to 20 ml of acetic anhydride and heated for 4 hours in oil-bath of 140°-150° C. After cooling, the resulting reaction mixture was poured into about ten-times volume of cold water to decompose excess acetic anhydride. The resulting precipitate was filtrated, washed with water and dried to obtain 4.5 g of crystal. The crystal was recrystallized from methyl alcohol to obtain 3 g of the desired product.
後処理
- temperatureheated for 4 hours in oil-bath of 140°-150° C
- temperatureAfter cooling
- customthe resulting reaction mixture
- filtrationThe resulting precipitate was filtrated
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-14e7ac18f05e4d2fa6efee89e661e553
- 出典データセット
- uspto-grants-1980_10
- 特許番号
- US04229465
反応ノート
読み込み中…