Tert-Butylamine → 4-(2-Hydroxy-3-tert.-butylamino-propoxy)-2-ethoxycarbonyl-6-methylindole

HRID 903916ノート

反応式

HRID 903916 の反応式
[O:1]1[CH2:20][CH:2]1[CH2:3][O:4][C:5]1[CH:13]=[C:12]([CH3:14])[CH:11]=[C:10]2[C:6]=1[CH:7]=[C:8]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[NH:9]2.[C:21]([NH2:25])([CH3:24])([CH3:23])[CH3:22]>>[OH:1][CH:2]([CH2:20][NH:25][C:21]([CH3:24])([CH3:23])[CH3:22])[CH2:3][O:4][C:5]1[CH:13]=[C:12]([CH3:14])[CH:11]=[C:10]2[C:6]=1[CH:7]=[C:8]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[NH:9]2

参加物

3

反応物 2

HCID 6385Tert-ButylamineHCID 205275294-(2,3-Epoxypropoxy)-2-ethoxycarbonyl-6-methyl indole

生成物 1

HCID 233355434-(2-Hydroxy-3-tert.-butylamino-propoxy)-2-ethoxycarbonyl-6-methylindole収率 71%

実験手順

1.7 g 4-(2,3-epoxypropoxy)-2-ethoxycarbonyl-6-methyl-indole are dissolved in 25 ml tert.-butylamine. The solution is stored at room temperature for three days and then evaporated in vacuum. The residue is triturated with ether and aspirated. The crude product is dissolved in hot acetic ester and the solution is mixed with 0.3 ml glacial acetic acid. The precipitate resulting after cooling of the solution is aspirated and dried. There is obtained 1.8 g (~71% of theory) of 4-(2-hydroxy-3-tert.-butylamino-propoxy)-2-ethoxycarbonyl-6-methylindole as acetate; m.p. 181°-183° C.

後処理

  1. customevaporated in vacuum
  2. customThe residue is triturated with ether
  3. dissolutionThe crude product is dissolved in hot acetic ester
  4. additionthe solution is mixed with 0.3 ml glacial acetic acid
  5. customThe precipitate resulting
  6. temperatureafter cooling of the solution
  7. customdried

出典と根拠

ORDレコード
ord-19836387e9c64fbdbc345a28c56ffee8
出典データセット
uspto-grants-1980_10
特許番号
US04229464

反応ノート

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