Ammonia → 4-Benzyloxy-2-carbamoyl-6-methyl indole

HRID 903923ノート

反応式

HRID 903923 の反応式
[CH2:1]([O:8][C:9]1[CH:17]=[C:16]([CH3:18])[CH:15]=[C:14]2[C:10]=1[CH:11]=[C:12]([C:19]([O:21]CC)=O)[NH:13]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:24]>CO>[CH2:1]([O:8][C:9]1[CH:17]=[C:16]([CH3:18])[CH:15]=[C:14]2[C:10]=1[CH:11]=[C:12]([C:19](=[O:21])[NH2:24])[NH:13]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 23335518Ethyl 4-(benzyloxy)-6-methyl-1H-indole-2-carboxylate

生成物 1

HCID 233355554-Benzyloxy-2-carbamoyl-6-methyl indole収率 46%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

20.0 g 4-benzyloxy-2-ethoxycarbonyl-6-methyl indole (see preparation of the primary products in connection with Example 1) are heated together with 200 ml each of methanol and liquid ammonia in the autoclave for 16 hours, to 100° C. The solution is evaporated and the residue is chromatographed on silica gel (fluxing agent: chloroform/methanol 98:2). There is obtained 8.5 g (~46% of theory) 4-benzyloxy-2-carbamoyl-6-methyl indole; m.p. 185°-187° C.

後処理

  1. custompreparation of the primary products in connection with Example 1)
  2. customThe solution is evaporated
  3. customthe residue is chromatographed on silica gel (fluxing agent: chloroform/methanol 98:2)

出典と根拠

ORDレコード
ord-bf0eb90eac3a4c789bc499fa9de57ff3
出典データセット
uspto-grants-1980_10
特許番号
US04229464

反応ノート

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