Potassium Hydroxide → 4-(Benzyloxy)-6-methylindole-2-carboxylic Acid

HRID 903925ノート

反応式

HRID 903925 の反応式
[CH2:1]([O:8][C:9]1[CH:17]=[C:16]([CH3:18])[CH:15]=[C:14]2[C:10]=1[CH:11]=[C:12]([C:19]([O:21]CC)=[O:20])[NH:13]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+]>C(O)C.O>[CH2:1]([O:8][C:9]1[CH:17]=[C:16]([CH3:18])[CH:15]=[C:14]2[C:10]=1[CH:11]=[C:12]([C:19]([OH:21])=[O:20])[NH:13]2)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 23335518Ethyl 4-(benzyloxy)-6-methyl-1H-indole-2-carboxylate

生成物 1

HCID 219043124-(Benzyloxy)-6-methylindole-2-carboxylic Acid収率 95%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

31.0 4-benzyloxy-2-ethoxycarbonyl-6-methyl indole (see preparation of the primary products in connection with Example 1) are heated to boiling in a mixture of 100 ml ethanol and 100 ml water during addition of 7.0 potassium hydroxide, for 2 to 3 hours. The ethanol is then evaporated in vacuum and the remaining, water alkaline solution is acidified with conc. hydrochloric acid. The resulting precipitate is aspirated, thoroughly washed with water and dried. There is obtained 27.6 g (~95% of theory) 4-benzyloxy-2-carboxy-6-methyl indole; m.p. 178°-180° C.

後処理

  1. custompreparation of the primary products in connection with Example 1)
  2. temperatureare heated
  3. customThe ethanol is then evaporated in vacuum
  4. washthoroughly washed with water
  5. customdried

出典と根拠

ORDレコード
ord-26c714820cd14c3caadd591155259e34
出典データセット
uspto-grants-1980_10
特許番号
US04229464

反応ノート

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