Imidazole → HCID 23333787、化合物

HRID 904144ノート

反応式

HRID 904144 の反応式
[CH3:1][N:2]([CH2:4][C:5]1[C:10]([OH:11])=[CH:9][CH:8]=[C:7]([CH3:12])[N:6]=1)[CH3:3].[NH:13]1C=CN=[CH:14]1>C1(C)C(C)=CC=CC=1>[N:2]1([CH2:4][C:5]2[C:10]([OH:11])=[CH:9][CH:8]=[C:7]([CH3:12])[N:6]=2)[CH:1]=[CH:14][N:13]=[CH:3]1

参加物

4

反応物 2

HCID 795ImidazoleHCID 233337942-[(Dimethylamino)methyl]-6-methyl-3-pyridinol

生成物 1

HCID 23333787HCID 23333787、化合物収率 76.3%

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

The procedure described in Example 1 was repeated except that 2-dimethylaminomethyl-3-hydroxy-6-methylpyridine (16.6 g.) and imidazole (6.8 g.) were reacted in xylene (50 ml.) to afford 2-(imidazol-1-ylmethyl)-3-hydroxy-6-methylpyridine (yield, 14.42 g.), m.p. 153°-155° C. after recrystallization from isopropanol/petroleum ether (b.p. 60°-80° C.).

出典と根拠

ORDレコード
ord-06271c6cf729436fb963977e705f650a
出典データセット
uspto-grants-1980_10
特許番号
US04230714

反応ノート

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