2-Amino-4-methylpyridine → 1-(4-Methyl-2-pyridinyl)-3-(tetrahydro-1-methyl-4-oxo-1H-imidazol-2-ylidene) urea
反応式
[CH3:1][N:2]1[CH2:6][C:5](=[O:7])[NH:4][C:3]1=[N:8][C:9](=[O:11])O.[NH2:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][N:14]=1>CN(C=O)C>[CH3:19][C:17]1[CH:16]=[CH:15][N:14]=[C:13]([NH:12][C:9]([N:8]=[C:3]2[NH:4][C:5](=[O:7])[CH2:6][N:2]2[CH3:1])=[O:11])[CH:18]=1参加物
4
反応条件
- 温度
- 25 °C
実験手順
A mixture of 3.0 g (12.8 mM) of the phenyl carbamate 8 and 2.8 g (25.7 mM) of 2-amino-4-methylpyridine in 25 ml of anhydrous DMF was stirred at 25° C. for 5 hrs., filtered and the filtrate diluted with 150 ml of water. The resulting precipitate was collected and recrystallized from ethanol to give 0.6 g of the above urea as a pale yellow solid, m.p. 231°-232° C. (dec.).
後処理
- filtration, filtered
- additionthe filtrate diluted with 150 ml of water
- customThe resulting precipitate was collected
- customrecrystallized from ethanol
出典と根拠
- ORDレコード
- ord-75b3931a461745ab84bad3a2f9495499
- 出典データセット
- uspto-grants-1980_10
- 特許番号
- US04230713
反応ノート
読み込み中…